© 2019 Opertech Bio, Inc.

 

PUBLICATIONS

Opertech's team has published a number of scientific papers and has made a number of scientific presentations.

 

Chang, H., Pohlhaus, D., Palmer R.K., Stewart M. "Does Stress

Impact the Sweetness Perception of Sweeteners?" 13th Pangborn Sensory Science Symposium, Edinburgh. Scotland, 2019.

 

Stewart, M., Palmer R.K. "TāStation®: A New High Throughput Technology

for Precise Measurement of Human Taste.13th Pangborn Sensory Science Symposium, Edinburgh. Scotland, 2019.

Stewart, M., Palmer R.K. "Automated High Throughput Objective

Assessment of Human Taste Palatability Predictive of Consumption." ASPET 2019. The American Society for Pharmacology and Experimental Therapeutics division of the annual Experimental Biology meeting, Orlando, FL, 2019.

 

Palmer R.K. "A Pharmacological Perspective on the Study of Taste."

Pharmacological Reviews, 71 (1) 20-48; DOI: https://doi.org/10.1124/pr.118.015974, January 2019

Stewart, M., Palmer R.K. "Generating concentration-response functions for

taste stimuli and identifying taste phenotypes through the TāStation®: an automated high throughput system for the measurement of human taste." SSP 2018, The Society of Sensory Professionals Conference, Cleveland, OH, 2018.

Palmer R.K., Stewart, M. "High Throughput Characterization of Aloin Bitter

Taste Phenotypes in Human Subjects.40th Meeting of the Association for Chemoreception Sciences, Bonita Springs, FL, 2018.

 

Stewart, M., Palmer R.K. "Automated High Throughput Generation of

Concentration-Response Functions for Bitter Taste in Human Subjects." Experimental Biology 2017, Chicago, IL, 2017.

Palmer R.K., Stewart, M. "Rapid Throughput Measurement of Sweet Taste

Using Human Subjects." 39th Meeting of the Association for Chemoreception Sciences, Bonita Springs, FL, 2017.

 

Stewart, M., Long, D.. Palmer R.K. “Rapid generation of concentration-

response functions for taste in human subjects using an automated 96-well platform and interactive algorithms for taste measurement.”  Neuroscience 2016, the Society for Neuroscience’s Annual Conference, San Diego, CA, 2016.

 

Palmer R.K., Stewart, M., Long, D. "A New Paradigm for Human Taste 

Measurement." 38th Meeting of the Association for Chemoreception Sciences, Bonita Springs, FL, 2016.

 

Palmer, R.K., Long, D., Brennan, F., Buber, T., Bryant, R., Salemme, F.R. "A

High Throughput In Vivo Assay for Taste Quality and Palatability." PLoS ONE 8(8): e72391. doi:10.1371/journal.pone.0072391, 2013.

 

Pawlyk, A.C., Palmer, R.K., Sprous, D., Allee, C. "A Generalized Model and

High Throughput Data Analysis System for Functional Modulation of Receptor-agonist Systems Suitable for Use in Drug Discovery." Combinatorial Chemistry and High Throughput Screening, 16:199-209, 2013.

 

Palmer, R.K., and Lunn, C.A. "TRP Channels as Targets for Therapeutic

Intervention in Obesity: Focus on TRPV1 and TRPM5." Current Topics in Medicinal Chemistry, in Press, 2013. ​

 

Palmer, R.K., Atwal, K., Bakaj, I., Carlucci-Derbyshire, S., Buber, M.T., Cerne,

R., Cortés, R.Y., Devantier, H.R., Jorgensen, V., Pawlyk, A., Lee, S.P., Sprous, D.G., Zhang, Z., and Bryant, R. "Triphenylphosphine Oxide is a Potent and Selective Inhibitor of the Transient Receptor Potential Melastatin-5 Ion Channel." Assay and Drug Development Technologies, 8:703-713, 2010.

 

Sprous, D.G., and Palmer, R.K. "The T1R2/T1R3 Sweet Receptor and TRPM5

Ion Channel: Taste Targets with Therapeutic Potential." In Progress in Molecular Biology and Translational Science: Membrane Proteins as Drug Targets (Edited by Charles A. Lunn), vol. 91, pp. 151-208, Academic Press, Burlington, 2010.

 

Sprous, D.G., Palmer, R.K., Swanson, J.T., and Lawless, M. "QSAR in the

Pharmaceutical Research Setting: QSAR Models for Broad, Large Problems." Current Topics in Medicinal Chemistry, 10: 619-637, 2010.

 

Long, D.J., Devantier, H.R., Brennan, F.X., Bryant, R.W., Salemme, F.R., and

Palmer, R.K. "Pharmacologic Antagonism of the Oral Aversive Taste-directed Response to Capsaicin in a Mouse Brief-access Taste Aversion Assay." Journal of Pharmacology and Experimental Therapeutics, 332:525-530, 2010. ​

 

Devantier, H.R., Long, D.J., Brennan, F.X., Carlucci, S.A., Hendrix, C., Bryant,

R.W., Salemme, F.R., and Palmer, R.K. "Quantitative Assessment of TRPM5-dependent Oral Aversiveness of Pharmaceuticals using a Mouse Brief-access Taste Aversion Assay." Behavioural Pharmacology, 19:673-682, 2008.

 

Sprous, D.G., and Salemme, F.R.​ "A Comparison of the Chemical Properties

of Drugs and FEMA/FDA notified GRAS Chemical Compounds Used in the Food Industry." Food and Chemical Toxicology, 45: 1419-1427, 2007. ​

 

Palmer, R.K. "The Pharmacology and Signaling of Bitter Sweet, and Umami

Taste Sensing." Molecular Interventions, 7(2):87-98, 2007.

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